9Z3N

Complex of phosphorylated p38-alpha and MK2 with a molecular glue

Summary for 9Z3N

Entry DOI	10.2210/pdb9z3n/pdb
Descriptor	Mitogen-activated protein kinase 14, MAP kinase-activated protein kinase 2, (1M,5P)-5-(2-chloro-4-fluorophenyl)-1-{(3P)-2,6-dichloro-3-[2-(2-hydroxypropan-2-yl)pyrimidin-4-yl]phenyl}quinazolin-2(1H)-one, ... (7 entities in total)
Functional Keywords	mapk, mapkapk, phosphorylated, p38, mk2, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	336836.25
Authors	Bell, J.A. (deposition date: 2025-11-07, release date: 2026-11-11)
Primary citation	Wang, G.,Konst, Z.A.,Dahlgren, M.K.,Arora, P.,Therrien, E.,So, S.,Bos, P.H.,Bell, J.A.,DiMattia, M.A.,Evangelista, E.A.,Zou, Y.,Futran, A.S.,Yao, K.,Boyles, N.,Halder, S.,Salmon, M.,Bhat, S.,Gerasyuto, A.I.,Igawa, H. Diverse Computational Strategies Enable the Discovery of p38-alpha-MK2 Molecular Glues To Be Published,
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation