9Z3N

Complex of phosphorylated p38-alpha and MK2 with a molecular glue

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Mitogen-activated protein kinase 14	polymer	363	41754.3	4	UniProt (Q16539)	Homo sapiens (human)	MAP kinase 14,MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSAID-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a
2	E, F, G, H (E, F, G, H)	MAP kinase-activated protein kinase 2	polymer	363	41786.3	4	UniProt (P49137)	Homo sapiens (human)	MAPK-activated protein kinase 2,MAPKAP kinase 2,MAPKAP-K2,MAPKAPK-2,MK-2,MK2
3	I, K, M, O (A, B, C, D)	(1M,5P)-5-(2-chloro-4-fluorophenyl)-1-{(3P)-2,6-dichloro-3-[2-(2-hydroxypropan-2-yl)pyrimidin-4-yl]phenyl}quinazolin-2(1H)-one	non-polymer		557.8	4	Chemie (A1C0A)
4	J, L, N, P (A, B, C, D)	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
5	Q (E)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
6	R (E)	MALONATE ION	non-polymer		102.0	1	Chemie (MLI) PubChem (9084)
7	S, T, U, V, W... (A, B, C, D, E...)	water	water		18.0	46	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 360 (UniProt: Q16539)

PDB	External Database	Details
Gly -2	-	expression tag
Gly -1	-	expression tag
Gly 0	-	expression tag

E, F, G, H: 41 - 400 (UniProt: P49137)

PDB	External Database	Details
Gly 38	-	expression tag
Gly 39	-	expression tag
Gly 40	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	334162.5
Non-Polymers*	Number of molecules	10
	Total formula weight	2673.7
All*	Total formula weight	336836.3

*Water molecules are not included.