9YOV

Cryo-EM structure of an active dimer of the C. elegans EGFR (LET-23) extracellular region with a domain IV loop deletion bound to LIN-3.

Summary for 9YOV

Entry DOI	10.2210/pdb9yov/pdb
EMDB information	73275 73276 73277 73278 73279
Descriptor	Receptor tyrosine-protein kinase let-23, Protein spitz,Protein lin-3, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	receptor tyrosine kinase, epidermal growth factor receptor, ligand-bound dimer, signaling protein
Biological source	Caenorhabditis elegans More
Total number of polymer chains	4
Total formula weight	209530.32
Authors	Zuo, Y.,Walker, K.,Han, L.,Ferguson, K.M. (deposition date: 2025-10-13, release date: 2026-07-29)
Primary citation	Zuo, Y.,Schwartz, H.T.,Walker, K.,Han, L.,Sternberg, P.W.,Ferguson, K.M. Ligand regulation and function of preformed EGFR dimers Proc.Natl.Acad.Sci.USA, 2026 Cited by DOI: 10.1073/pnas.2602436123 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.36 Å)

Structure validation