9YOV

Cryo-EM structure of an active dimer of the C. elegans EGFR (LET-23) extracellular region with a domain IV loop deletion bound to LIN-3.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Receptor tyrosine-protein kinase let-23	polymer	792	90095.2	2	UniProt (P24348)	Caenorhabditis elegans	Lethal protein 23
2	B, D (C, D)	Protein spitz,Protein lin-3	polymer	104	11781.3	2	UniProt (Q01083) UniProt (Q03345)	Caenorhabditis elegans	Abnormal cell lineage protein 3,Lethal protein 94
3	E, J (E, J)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB
4	F, G, H, I, K... (F, G, H, I, K...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	8	In PDB
5	O, P, Q, R (A, C, B, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

A, B: 27 - 593 (UniProt: P24348)

PDB	External Database	Details
-	Tyr 594	deletion
-	Asn 595	deletion
-	Ser 596	deletion
-	Asp 597	deletion
-	Phe 598	deletion
-	Gly 599	deletion
-	Asn 600	deletion
-	Arg 601	deletion
-	Met 602	deletion

A, B: 596 - 812 (UniProt: P24348)

PDB	External Database	Details
Gly 594	-	insertion
Gly 595	-	insertion
His 813	-	expression tag
His 814	-	expression tag
His 815	-	expression tag
His 816	-	expression tag
His 817	-	expression tag
His 818	-	expression tag

C, D: 110 - 142 (UniProt: Q01083)

PDB	External Database	Details
Arg 103	-	expression tag
His 104	-	expression tag
His 105	-	expression tag
His 106	-	expression tag
His 107	-	expression tag
His 108	-	expression tag
His 109	-	expression tag
Ile 143	-	insertion
Glu 144	-	insertion
Gly 145	-	insertion
Arg 146	-	insertion
Ser 147	-	conflict

C, D: 148 - 206 (UniProt: Q03345)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	203752.9
Branched	Number of molecules	10
	Total formula weight	4892.6
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	209530.3

*Water molecules are not included.