9YOU

Cryo-EM structure of a weak dimer of the C. elegans EGFR (LET-23) extracellular region with a domain IV loop deletion

This is a non-PDB format compatible entry.

Summary for 9YOU

• Entry DOI: 10.2210/pdb9you/pdb
• EMDB information: 73275 73276 73277 73278 73279
• Descriptor: Receptor tyrosine-protein kinase let-23, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: receptor tyrosine kinase, epidermal growth factor receptor, preformed dimer, signaling protein
• Biological source: Caenorhabditis elegans; More
• Total number of polymer chains: 2
• Total formula weight: 185849.61

Authors

Zuo, Y.,Walker, K.,Han, L.,Ferguson, K.M. (deposition date: 2025-10-13, release date: 2026-07-29)

• Primary citation: Zuo, Y.,Schwartz, H.T.,Walker, K.,Han, L.,Sternberg, P.W.,Ferguson, K.M.; Ligand regulation and function of preformed EGFR dimers; Proc.Natl.Acad.Sci.USA, 2026; DOI: 10.1073/pnas.2602436123

Experimental method

ELECTRON MICROSCOPY (4 Å)