9YOU

Cryo-EM structure of a weak dimer of the C. elegans EGFR (LET-23) extracellular region with a domain IV loop deletion

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Receptor tyrosine-protein kinase let-23	polymer	792	90095.2	2	UniProt (P24348)	Caenorhabditis elegans	Lethal protein 23
2	C, H (C, H)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB
3	D, E, G, I, J... (D, E, G, I, J...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB
4	F, K (F, K)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB
5	M, N (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A, B: 27 - 593 (UniProt: P24348)

PDB	External Database	Details
-	Tyr 594	deletion
-	Asn 595	deletion
-	Ser 596	deletion
-	Asp 597	deletion
-	Phe 598	deletion
-	Gly 599	deletion
-	Asn 600	deletion
-	Arg 601	deletion
-	Met 602	deletion

A, B: 596 - 812 (UniProt: P24348)

PDB	External Database	Details
Gly 594	-	insertion
Gly 595	-	insertion
His 813	-	expression tag
His 814	-	expression tag
His 815	-	expression tag
His 816	-	expression tag
His 817	-	expression tag
His 818	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	180190.3
Branched	Number of molecules	10
	Total formula weight	5216.9
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	185849.6

*Water molecules are not included.