9YCD

Leucine Rich Repeat Kinase 2 R1441C mutant (active)

Summary for 9YCD

Entry DOI	10.2210/pdb9ycd/pdb
EMDB information	72768
Descriptor	Leucine-rich repeat serine/threonine-protein kinase 2, (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine (2 entities in total)
Functional Keywords	kinase, gtpases, lrrk2, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	286788.17
Authors	Villagran Suarez, A.,Bodrug, T.,Leschziner, A. (deposition date: 2025-09-18, release date: 2026-08-19)
Primary citation	Villagran Suarez, A.,Hatch, K.S.,Bodrug, T.,Gai, W.,Surridge, K.J.,Moussikhina, E.,Nguyen, K.H.,Sanz-Murillo, M.,Callahan, R.,Xiong, E.,Ramos, D.,Zhu, L.,Dederer, V.,Mathea, S.,Iwasa, J.,Knapp, S.,Shokat, K.M.,Reck-Peterson, S.L.,Leschziner, A.E. The structural basis for LRRK2's activation and autoinhibition Cell(Cambridge,Mass.), 2026 Cited by DOI: 10.1016/j.cell.2026.07.027 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.63 Å)

Structure validation