9Y7T

Crystal structure of Candida auris dihydrofolate reductase in complex with inhibitor 1172 and NADPH

Summary for 9Y7T

• Entry DOI: 10.2210/pdb9y7t/pdb
• Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid, ... (6 entities in total)
• Functional Keywords: dihydrofolate reductase candida auris inhibitor complex, oxidoreductase
• Biological source: Candidozyma auris
• Total number of polymer chains: 2
• Total formula weight: 50066.45

Authors

Erlandsen, H.,Krucinska, J.,Wright, D. (deposition date: 2025-09-11, release date: 2026-07-22)

• Primary citation: Erlandsen, H.,Krucinska, J.,Wright, D.; Structural and biological evaluation of non-classical antifolates as antifungal drug candidates targeting Candia auris dihydrofolate reductase.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.98 Å)