9Y7Q

Crystal structure of Candida auris dihydrofolate reductase in complex with inhibitor 1051 (S-form) and NADPH

This is a non-PDB format compatible entry.

Summary for 9Y7Q

• Entry DOI: 10.2210/pdb9y7q/pdb
• Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-[(3S)-3-(6-phenylpyridin-3-yl)but-1-yn-1-yl]pyrimidine-2,4-diamine, ... (4 entities in total)
• Functional Keywords: inhibitor complex, oxidoreductase
• Biological source: Candidozyma auris
• Total number of polymer chains: 2
• Total formula weight: 50272.91

Authors

Erlandsen, H.,Wright, D.,Krucinska, J. (deposition date: 2025-09-11, release date: 2026-07-22)

• Primary citation: Erlandsen, H.,Wright, D.,Krucinska, J.; Structural and biological evaluation of non-classical antifolates as antifungal drug candidates targeting Candia auris dihydrofolate reductase.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.42 Å)