9Y7O

Cryo-EM structure of PI(3,5)P2 and ML-SA1 bound full-length mouse TRPML2 channel in lipid nanodisc, closed I

Summary for 9Y7O

• Entry DOI: 10.2210/pdb9y7o/pdb
• EMDB information: 72662
• Descriptor: Mucolipin-2, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione (3 entities in total)
• Functional Keywords: cation channel, membrane protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 4
• Total formula weight: 266518.36

Authors

Park, S.,Yang, J. (deposition date: 2025-09-10, release date: 2026-09-16)

• Primary citation: Park, S.,Yang, J.; Conformational landscape of synergistic activation of mouse TRPML2 channel; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.01 Å)