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Cryo-EM structure of PI(3,5)P2 and ML-SA1 bound full-length mouse TRPML2 channel in lipid nanodisc, closed I

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, C, B, D)	Mucolipin-2	polymer	566	65520.6	4	UniProt (Q8K595) Pfam (PF21381) Pfam (PF08016)	Mus musculus (house mouse)	Transient receptor potential channel mucolipin 2,TRPML2
2	E, G, I, K (A, C, B, D)	(2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate	non-polymer		746.6	4	Chemie (EUJ)
3	F, H, J, L (A, C, B, D)	2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione	non-polymer		362.4	4	Chemie (AQV) PubChem (1364417)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	262082.4
Non-Polymers*	Number of molecules	8
	Total formula weight	4436.0
All*	Total formula weight	266518.4

*Water molecules are not included.