9Y77

Cryo-EM structure of Mycobacterium tuberculosis transcription initiation complex in complex with UMN141

This is a non-PDB format compatible entry.

Summary for 9Y77

• Entry DOI: 10.2210/pdb9y77/pdb
• EMDB information: 72644
• Descriptor: DNA-directed RNA polymerase subunit alpha, MAGNESIUM ION, DNA-directed RNA polymerase subunit beta, ... (10 entities in total)
• Functional Keywords: transcription initiation complex, mycobacterium tuberculosis, umn141, inhibitor, antibacterial agent, transcription, transferase-dna-rna-inhibitor complex, transferase/dna/rna/inhibitor
• Biological source: Mycobacterium tuberculosis H37Rv; More
• Total number of polymer chains: 8
• Total formula weight: 467441.74

Authors

You, L.L.,Ebright, R.H. (deposition date: 2025-09-09, release date: 2026-09-30)

• Primary citation: You, L.L.,Ebright, R.H.; Structure-Driven Reengineering of Rifabutin Analogs Restores Activity Against Multidrug-Resistant Tuberculosis; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.58 Å)