9Y77
Cryo-EM structure of Mycobacterium tuberculosis transcription initiation complex in complex with UMN141
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00715 |
| Number of Residues | 14 |
| Details | SIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnLGLIrAV |
| Chain | Residue | Details |
| F | ASP319-VAL332 |
| site_id | PS00716 |
| Number of Residues | 27 |
| Details | SIGMA70_2 Sigma-70 factors family signature 2. TldEIGqvygVTrerIrQIEsktMskL |
| Chain | Residue | Details |
| F | THR488-LEU514 |
| site_id | PS00867 |
| Number of Residues | 8 |
| Details | CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANLRL |
| Chain | Residue | Details |
| F | LEU295-LEU302 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 225 |
| Details | Region: {"description":"Alpha N-terminal domain (alpha-NTD)","evidences":[{"source":"HAMAP-Rule","id":"MF_00059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 34 |
| Details | Region: {"description":"Sigma-70 factor domain-1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 70 |
| Details | Region: {"description":"Sigma-70 factor domain-2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 76 |
| Details | Region: {"description":"Sigma-70 factor domain-3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 53 |
| Details | Region: {"description":"Sigma-70 factor domain-4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Motif: {"description":"Interaction with polymerase core subunit RpoC"} |
| Chain | Residue | Details |
