9Y58

Nef SF2 dimerization mutant bound to Hck SH3

Summary for 9Y58

• Entry DOI: 10.2210/pdb9y58/pdb
• Descriptor: C-terminal core protein, Tyrosine-protein kinase HCK (3 entities in total)
• Functional Keywords: dimerization mutant, sh3 domain-binding, hiv, complex, viral protein
• Biological source: HIV-1 M:B_ARV2/SF2; More
• Total number of polymer chains: 2
• Total formula weight: 26106.31

Authors

Thomas, C.E.,Alvarado, J.J.,Smithgall, T.E. (deposition date: 2025-09-04, release date: 2026-07-15)

• Primary citation: Thomas, C.E.,Alvarado, J.J.,Smithgall, T.E.; HIV-1 Nef Homodimerization as a Structural Mechanism for Kinase Activation and Small Molecule Inhibitor Action; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.25 Å)