9Y4L

CryoEM Structure of human MDA5 in complex with dsRNA (two protein subunits on dsRNA)

Summary for 9Y4L

• Entry DOI: 10.2210/pdb9y4l/pdb
• EMDB information: 72485
• Descriptor: Interferon-induced helicase C domain-containing protein 1, RNA (30-MER), PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• Functional Keywords: rlr, mda5, filament, dsrna, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 187598.69

Authors

Xu, L.,Chung, K.,Pyle, A. (deposition date: 2025-09-03, release date: 2026-09-09)

• Primary citation: Xu, L.,Chung, K.,Guo, R.,Pan, A.,Pyle, A.M.; Unraveling the molecular basis for MDA5 T331I disease-linked mutation; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.96 Å)