9Y4L
CryoEM Structure of human MDA5 in complex with dsRNA (two protein subunits on dsRNA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, G) | Interferon-induced helicase C domain-containing protein 1 | polymer | 728 | 83702.4 | 2 | UniProt (Q9BYX4) | Homo sapiens (human) | Clinically amyopathic dermatomyositis autoantigen 140 kDa,CADM-140 autoantigen,Helicase with 2 CARD domains,Helicard,Interferon-induced with helicase C domain protein 1,Melanoma differentiation-associated protein 5,MDA-5,Murabutide down-regulated protein,RIG-I-like receptor 2,RLR-2,RNA helicase-DEAD box protein 116 |
| 2 | C (B) | RNA (30-MER) | polymer | 30 | 9664.7 | 1 | in vitro transcription vector pT7-Fluc(deltai) | ||
| 3 | D (C) | RNA (30-MER) | polymer | 30 | 9516.7 | 1 | in vitro transcription vector pT7-Fluc(deltai) | ||
| 4 | E, F (A, G) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 186586.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1012.4 | |
| All* | Total formula weight | 187598.7 |
