9Y1Q

Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (Composite map from PHENIX)

Summary for 9Y1Q

• Entry DOI: 10.2210/pdb9y1q/pdb
• EMDB information: 72403
• Descriptor: Cystic fibrosis transmembrane conductance regulator, PALMITIC ACID, MYRISTIC ACID, ... (18 entities in total)
• Functional Keywords: cystic fibrosis, cftr, nanobody, protein folding, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 203339.01

Authors

Hunt, J.F.,Paige, A.S.,Govaerts, C. (deposition date: 2025-08-30, release date: 2026-09-09)

• Primary citation: Hunt, F.J.,Paige, A.S.,Cohen, B.M.,Goldberg, P.M.,Wang, C.,Loughlin, B.J.,Kappes, J.C.,Yang, Z.,Jiang, F.,Govaerts, C.,Overtus, M.,Urbatsch, I.L.,Lukacs, G.; Nanobody-Driven Stabilization Synergistically Rescues F508del-CFTR and Reveals an Alternative Active State of the Channel; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.86 Å)