9Y1Q
Alternative NBD1-binding geometry in channel-formed, ATP-bound, VX809-bound, T2a-nanobody-bound wild-type human CFTR (Composite map from PHENIX)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cystic fibrosis transmembrane conductance regulator | polymer | 1523 | 172735.0 | 1 | UniProt (P13569) | Homo sapiens (human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B (B) | T2a nanobody | polymer | 146 | 15820.3 | 1 | Lama glama | ||
| 3 | C (C) | UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK-UNK | polymer | 17 | 1464.8 | 1 | Homo sapiens | ||
| 4 | D (A) | Digitonin | non-polymer | 1229.3 | 1 | Chemie (AJP) PubChem (6474107) | |||
| 5 | E, F, G, X (A) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) PubChem (5997) | |||
| 6 | H, I (A) | O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine | non-polymer | 792.1 | 2 | Chemie (P5S) | |||
| 7 | J, U (A) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 2 | Chemie (PC1) | |||
| 8 | AA, K, Z (A) | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE | non-polymer | 705.0 | 3 | Chemie (3PH) PubChem (447938) | |||
| 9 | L, T (A) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 2 | Chemie (PTY) | |||
| 10 | M, N, O, Y (A) | PALMITIC ACID | non-polymer | 256.4 | 4 | Chemie (PLM) PubChem (985) | |||
| 11 | P (A) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) PubChem (11005) | |||
| 12 | Q, V, W (A) | DODECANE | non-polymer | 170.3 | 3 | Chemie (D12) PubChem (5359624) PubChem (8182) | |||
| 13 | R (A) | DECANE | non-polymer | 142.3 | 1 | Chemie (D10) PubChem (15600) | |||
| 14 | BA, DA, S (A) | HEXANE | non-polymer | 86.2 | 3 | Chemie (HEX) PubChem (8058) | |||
| 15 | CA (A) | N-OCTANE | non-polymer | 114.2 | 1 | Chemie (OCT) PubChem (356) | |||
| 16 | EA, GA (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 17 | FA, HA (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 18 | IA (A) | Lumacaftor | non-polymer | 452.4 | 1 | Chemie (VX8) PubChem (16678941) |
Sequence modifications
A: 1 - 1480 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Met 470 | Val 470 | variant |
| Leu 1481 | - | expression tag |
| Glu 1482 | - | expression tag |
| Glu 1483 | - | expression tag |
| Asn 1484 | - | expression tag |
| Leu 1485 | - | expression tag |
| Tyr 1486 | - | expression tag |
| Phe 1487 | - | expression tag |
| Gln 1488 | - | expression tag |
| Gly 1489 | - | expression tag |
| Gly 1490 | - | expression tag |
| Gly 1491 | - | expression tag |
| Gly 1492 | - | expression tag |
| Ser 1493 | - | expression tag |
| Gly 1494 | - | expression tag |
| Gly 1495 | - | expression tag |
| Ser 1496 | - | expression tag |
| Trp 1497 | - | expression tag |
| Ser 1498 | - | expression tag |
| His 1499 | - | expression tag |
| Pro 1500 | - | expression tag |
| Gln 1501 | - | expression tag |
| Phe 1502 | - | expression tag |
| Glu 1503 | - | expression tag |
| Lys 1504 | - | expression tag |
| Ala 1505 | - | expression tag |
| Ala 1506 | - | expression tag |
| Ala 1507 | - | expression tag |
| Gly 1508 | - | expression tag |
| Gly 1509 | - | expression tag |
| Gly 1510 | - | expression tag |
| Ser 1511 | - | expression tag |
| Gly 1512 | - | expression tag |
| Gly 1513 | - | expression tag |
| Gly 1514 | - | expression tag |
| Ser 1515 | - | expression tag |
| Trp 1516 | - | expression tag |
| Ser 1517 | - | expression tag |
| His 1518 | - | expression tag |
| Pro 1519 | - | expression tag |
| Gln 1520 | - | expression tag |
| Phe 1521 | - | expression tag |
| Glu 1522 | - | expression tag |
| Lys 1523 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 190020.1 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 13318.9 | |
| All* | Total formula weight | 203339.0 |
