9XYH

Human mitochondrial ClpP in complex with OICR-18704 in the heptameric state

This is a non-PDB format compatible entry.

Summary for 9XYH

• Entry DOI: 10.2210/pdb9xyh/pdb
• EMDB information: 72334
• Descriptor: ATP-dependent Clp protease proteolytic subunit, mitochondrial, 4-[4-({7-chloro-3-[(1S)-1-cyanoethyl]-4-oxo-3,4-dihydroquinazolin-2-yl}methyl)piperazin-1-yl]-2-(trifluoromethyl)benzonitrile (3 entities in total)
• Functional Keywords: protease, proteolysis, hydrolase, complex with inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 7
• Total formula weight: 170260.93

Authors

Uday, A.B.,Zeytuni, N.,Goncalves, M.,Vahidi, S. (deposition date: 2025-08-26, release date: 2026-10-14)

• Primary citation: Goncalves, M.M.,Uday, A.B.,Watson, I.D.G.,Chau, A.M.,Kalhor-Monfared, S.,Wan, B.,Kiyota, T.,Currie, S.Q.W.,Jitkova, Y.,Feng, Y.,Diamandas, M.,Ling, D.,Ma, M.,Mancini, R.S.,Wang, Z.,Casas-Selves, M.,Joshi, D.,Mohammed, M.,Subramaniam, R.,Fernandes, E.L.,Yan, Y.,Pomroy, N.,Hurren, R.,Gronda, M.,Velyvis, A.,Yudin, A.K.,Reed, M.A.,Prive, G.,Aman, A.,Isaac, M.,Marcellus, R.,Uehling, D.,Schimmer, A.D.,Zeytuni, N.,Vahidi, S.; Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site; Nat Commun, 2026; DOI: 10.1038/s41467-026-78140-5

Experimental method

ELECTRON MICROSCOPY (3.4 Å)