9XXT

Cryo-EM structure of lysophosphatidylserine (18:0)-bound GPR174-Gs complex

This is a non-PDB format compatible entry.

Summary for 9XXT

• Entry DOI: 10.2210/pdb9xxt/pdb
• EMDB information: 67374
• Descriptor: Probable G-protein coupled receptor 174, Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
• Functional Keywords: complex, selectivity, water cavity, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 141983.83

Authors

Dong, Y.-J.,Xi, K.,Zhang, Y.-Z.,Xue, J.-H.,Shen, D.-D.,Zang, S.-K.,Zhao, R.-Z.,Qi, H.,Mao, C.-Y.,Wang, W.-W.,Zhang, Y. (deposition date: 2025-12-01, release date: 2026-04-15)

• Primary citation: Dong, Y.-J.,Xi, K.,Zhang, Y.-Z.,Xue, J.-H.,Shen, D.-D.,Zang, S.-K.,Zhao, R.-Z.,Qi, H.,Mao, C.,Wang, W.-W.,Zhang, Y.; Hydration network drives activation and G protein selectivity in GPR174; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2 Å)