9XH4

Cryo-EM structure of unnatural-base aptamer AptD1 with DENV1 NS1 hexamer

Summary for 9XH4

• Entry DOI: 10.2210/pdb9xh4/pdb
• EMDB information: 66866
• Descriptor: Non-structural protein 1, unnatural-base aptamer AptD1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: non-structural protein, unnatural-base aptamer, viral protein, viral protein-dna complex, viral protein/dna
• Biological source: Dengue virus 1 Nauru/West Pac/1974; More
• Total number of polymer chains: 9
• Total formula weight: 302364.13

Authors

Sawada, K.,Sano, F.K.,Shuto, Y.,Hirano, H.,Kusakizako, T.,Itoh, Y.,Kise, Y.,Nureki, O. (deposition date: 2025-10-31, release date: 2026-11-04)

• Primary citation: Sawada, K.,Kimoto, M.,Matsunaga, K.,Tan, H.P.,Takayanagi, R.,Sano, F.K.,Shuto, Y.,Hirano, H.,Kusakizako, T.,Itoh, Y.,Kise, Y.,Hirao, I.,Nureki, O.; Structural Insights into Enhanced Binding Affinity and Specificity of Six-Letter DNA Aptamers to Dengue Antigen NS1 Proteins via Genetic Alphabet Expansion; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.72 Å)