9XH4

Cryo-EM structure of unnatural-base aptamer AptD1 with DENV1 NS1 hexamer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, D, F, G... (A, B, C, E, F...)	Non-structural protein 1	polymer	370	42131.8	6	UniProt (P17763)	Dengue virus 1 Nauru/West Pac/1974	NS1
2	B, E, H (G, D, H)	unnatural-base aptamer AptD1	polymer	48	15016.7	3		synthetic construct
3	J, K, M, N, O... (A, B, C, E, F...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	12	Chemie (NAG) PubChem (24139)
4	L, Q, V (B, E, I)	DIUNDECYL PHOSPHATIDYL CHOLINE	non-polymer		622.8	3	Chemie (PLC)

Sequence modifications

A, B, C, E, F, I: 1 - 352 (UniProt: P17763)

PDB	External Database	Details
Ala -1	-	expression tag
Ser 0	-	expression tag
Glu 353	-	expression tag
Asn 354	-	expression tag
Leu 355	-	expression tag
Tyr 356	-	expression tag
Phe 357	-	expression tag
Gln 358	-	expression tag
Gly 359	-	expression tag
Ala 360	-	expression tag
Ala 361	-	expression tag
Ala 362	-	expression tag
His 363	-	expression tag
His 364	-	expression tag
His 365	-	expression tag
His 366	-	expression tag
His 367	-	expression tag
His 368	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	297841.1
Non-Polymers*	Number of molecules	15
	Total formula weight	4523.0
All*	Total formula weight	302364.1

*Water molecules are not included.