9X20

Cryo-EM structure of the GLP-1-bound human GLP-1R-Gi complex

Summary for 9X20

• Entry DOI: 10.2210/pdb9x20/pdb
• EMDB information: 66468
• Descriptor: Glucagon-like peptide 1(7-36), Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (6 entities in total)
• Functional Keywords: glp-1r, signaling protein/immune system, signaling protein-immune system complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 167223.83

Authors

Zhou, Q.T.,Zhou, Q.T. (deposition date: 2025-10-03, release date: 2026-05-06)

• Primary citation: Zhou, Q.,Li, J.,Zhang, Y.,Cai, X.,Han, W.,Yang, D.,Wang, M.W.; Distinctive molecular architectures of G q - and G i -coupled GLP-1 receptors.; Acta Pharm Sin B, 16:1779-1785, 2026; PubMed: 41909725; DOI: 10.1016/j.apsb.2026.01.023

Experimental method

ELECTRON MICROSCOPY (3.18 Å)