9WXH

Cryo-EM structure of the type III-D2 CRISPR-Cas effector complex bound to a cognate target RNA in the pre-cleavage state

Summary for 9WXH

• Entry DOI: 10.2210/pdb9wxh/pdb
• EMDB information: 66346
• Descriptor: CRISPR RNA, Cas10, CRISPR type III-associated protein domain-containing protein, ... (10 entities in total)
• Functional Keywords: crispr, anti-phage defense, second messenger, sam-amp, immune system
• Biological source: Gammaproteobacteria bacterium; More
• Total number of polymer chains: 5
• Total formula weight: 307022.32

Authors

Mitsuda, Y.,Ishikawa, J.,Nagahata, N.,Hiraizumi, M.,Yamashita, K.,Nishimasu, H. (deposition date: 2025-09-25, release date: 2026-06-24)

• Primary citation: Mitsuda, Y.,Sugaya, M.,Ishikawa, J.,Nagahata, N.,Okazaki, S.,Hiraizumi, M.,Kato, K.,Gootenberg, J.S.,Abudayyeh, O.O.,Osawa, T.,Yamashita, K.,Nishimasu, H.; Structural mechanism of SAM-AMP synthesis by the type III-D2 CRISPR effector complex; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.6 Å)