9WGM

Crystal structure of the OcuKAI2d2 protein from Orobanche cumana

Summary for 9WGM

• Entry DOI: 10.2210/pdb9wgm/pdb
• Descriptor: Alpha/beta-hydrolases superfamily protein (2 entities in total)
• Functional Keywords: ockai2d2, dehydrocostus lactone, receptor, enzyme, hydrolase
• Biological source: Orobanche cernua var. cumana
• Total number of polymer chains: 1
• Total formula weight: 29621.89

Authors

Hameed, U.F.S.,Arold, S.T. (deposition date: 2025-08-25, release date: 2026-05-20)

Primary citation

Shahul Hameed, U.F.,Jamil, M.,Zarban, R.,Saito, Y.,Alashoor, K.,Balakrishna, A.,Asami, T.,Arold, S.T.,Al-Babili, S.
Orobanche cumana KAI2d2 mediates perception of dehydrocostus lactone and strigolactones and is inhibited by triazole ureas.
Plant Commun., :101889-101889, 2026

PubMed Abstract: Seed germination of the parasitic plant Orobanche cumana is induced by host-derived strigolactones and dehydrocostus lactone. We show that the KAI2d2 receptor perceives both ligands through distinct modes of interaction. Triazole urea compounds covalently inhibit KAI2d receptors, suppressing germination without affecting sunflower growth.

PubMed: 42104616
DOI: 10.1016/j.xplc.2026.101889

Experimental method

X-RAY DIFFRACTION (2.19 Å)