9WFK

Crystal structure of FGFR1 kinase domain in complex with LJ5368((2R,3R,4S,5R)-2-(4-amino-5-(7-methoxy-5-methylbenzo[b]thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol)

This is a non-PDB format compatible entry.

Summary for 9WFK

• Entry DOI: 10.2210/pdb9wfk/pdb
• Descriptor: Fibroblast growth factor receptor 1, (2~{R},3~{R},4~{S},5~{R})-2-[4-azanyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(hydroxymethyl)oxolane-3,4-diol, GLYCEROL, ... (4 entities in total)
• Functional Keywords: pan-fgfr inhibitors, covalent inhibitors, nucleoside analogs, molecular dynamic simulations, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 71133.64

Authors

Moon, S.H.,Ko, H.L.,Han, B.W. (deposition date: 2025-08-21, release date: 2026-08-26)

• Primary citation: Moon, S.H.,Ko, H.L.,Park, J.H.,Jeong, L.S.; Crystal structure of FGFR1 kinase domain in complex with LJ5368((2R,3R,4S,5R)-2-(4-amino-5-(7-methoxy-5-methylbenzo[b]thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.89 Å)