9WFK
Crystal structure of FGFR1 kinase domain in complex with LJ5368((2R,3R,4S,5R)-2-(4-amino-5-(7-methoxy-5-methylbenzo[b]thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 1 | polymer | 308 | 35078.3 | 2 | UniProt (P11362) | Homo sapiens (human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1 |
| 2 | C, D (A, B) | (2~{R},3~{R},4~{S},5~{R})-2-[4-azanyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(hydroxymethyl)oxolane-3,4-diol | non-polymer | 442.5 | 2 | Chemie (A1MBJ) | |||
| 3 | E (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 325 | Chemie (HOH) |
Sequence modifications
A, B: 458 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Ala 488 | Cys 488 | engineered mutation |
| Ser 584 | Cys 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70156.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 977.1 | |
| All* | Total formula weight | 71133.6 |
