9WDO

Cryo-EM structure of the human PKR tetramer with mitapivat (C2 symmetric, dual-bound state)

Summary for 9WDO

• Entry DOI: 10.2210/pdb9wdo/pdb
• EMDB information: 65437 65641 65736 65893
• Descriptor: Pyruvate kinase PKLR, mitapivat (3 entities in total)
• Functional Keywords: pyruvate kinase pklr, rpk, glycolysis, allosteric regulation, erythroid-specific, pkd, mitapivat(ag-348), transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 249418.30

Authors

Ma, H.Y.,Su, Z.M. (deposition date: 2025-08-19, release date: 2026-08-26)

• Primary citation: Ma, H.Y.,Su, Z.M.; Structural insights into allosteric activation of pyruvate kinase R by mitapivat and novel agonists; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.57 Å)