9WDO
Cryo-EM structure of the human PKR tetramer with mitapivat (C2 symmetric, dual-bound state)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pyruvate kinase PKLR | polymer | 574 | 61904.0 | 4 | UniProt (P30613) | Homo sapiens (human) | Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase |
| 2 | E, F, G, H (A, C, D) | mitapivat | non-polymer | 450.6 | 4 | Chemie (WV2) PubChem (59634741) | |||
| 3 | I, J, K (A, C, D) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 247616.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1802.2 | |
| All* | Total formula weight | 249418.3 |
