9W81
Cryo-EM structure of human pyruvate kinase R (PKR) in complex with an allosteric activator FT-4202
This is a non-PDB format compatible entry.
Summary for 9W81
| Entry DOI | 10.2210/pdb9w81/pdb |
| EMDB information | 65437 65641 65736 65737 |
| Descriptor | Pyruvate kinase PKLR, (2~{R})-1-[5-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-ylsulfonyl)-1,3,4,6-tetrahydropyrrolo[3,4-c]pyrrol-2-yl]-3-oxidanyl-2-phenyl-propan-1-one (2 entities in total) |
| Functional Keywords | pyruvate kinase pklr, glycolysis, allosteric regulation, erythroid-specific, pkd, translocase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 4 |
| Total formula weight | 248531.09 |
| Authors | |
| Primary citation | Ma, H.Y.,Su, Z.M. Structural insights into allosteric activation of pyruvate kinase R by mitapivat and novel agonists To Be Published, |
| Experimental method | ELECTRON MICROSCOPY (2.81 Å) |
Structure validation
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