9W81

Cryo-EM structure of human pyruvate kinase R (PKR) in complex with an allosteric activator FT-4202

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Pyruvate kinase PKLR	polymer	574	61904.0	4	UniProt (P30613) Pfam (PF00224) Pfam (PF02887)	Homo sapiens (human)	Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase
2	E, F (B, C)	(2~{R})-1-[5-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-ylsulfonyl)-1,3,4,6-tetrahydropyrrolo[3,4-c]pyrrol-2-yl]-3-oxidanyl-2-phenyl-propan-1-one	non-polymer		457.5	2	Chemie (A1EVM)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	247616.1
Non-Polymers*	Number of molecules	2
	Total formula weight	915.0
All*	Total formula weight	248531.1

*Water molecules are not included.