9W4Q

Cryo-EM structure of human pyruvate kinase R (PKR) in complex with an allosteric activator SNH-119014

This is a non-PDB format compatible entry.

Summary for 9W4Q

• Entry DOI: 10.2210/pdb9w4q/pdb
• EMDB information: 65437 65641
• Descriptor: Pyruvate kinase PKLR, (2~{S})-2-[2,4-bis(fluoranyl)phenyl]-3-oxidanyl-1-[3-(1-pyridin-2-ylsulfonylazetidin-3-ylidene)azetidin-1-yl]propan-1-one (2 entities in total)
• Functional Keywords: pyruvate kinase pklr, glycolysis, allosteric regulation, erythroid-specific, translocase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 248486.98

Authors

Ma, H.Y.,Su, Z.M. (deposition date: 2025-08-01, release date: 2026-08-05)

• Primary citation: Ma, H.Y.,Su, Z.M.; Structural insights into allosteric activation of pyruvate kinase R by mitapivat and novel agonists; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.77 Å)