9W4Q

Cryo-EM structure of human pyruvate kinase R (PKR) in complex with an allosteric activator SNH-119014

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Pyruvate kinase PKLR	polymer	574	61904.0	4	UniProt (P30613)	Homo sapiens (human)	Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase
2	E, F (B, C)	(2~{S})-2-[2,4-bis(fluoranyl)phenyl]-3-oxidanyl-1-[3-(1-pyridin-2-ylsulfonylazetidin-3-ylidene)azetidin-1-yl]propan-1-one	non-polymer		435.4	2	Chemie (A1EU3)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	247616.1
Non-Polymers*	Number of molecules	2
	Total formula weight	870.9
All*	Total formula weight	248487.0

*Water molecules are not included.