9W2G

Cryo-EM structure of EB1001-bound neurokinin 2 receptor (NK2R) in complex with miniGs/q70

Summary for 9W2G

• Entry DOI: 10.2210/pdb9w2g/pdb
• EMDB information: 65570
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Nanobody 35, ... (6 entities in total)
• Functional Keywords: gpcr, eb1001, neurokinin 2 receptor (nk2r), active state, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 134684.31

Authors

Ren, Y.,Pavlovskyil, A.,Liu, X.,Gerhart-Hines, Z. (deposition date: 2025-07-27, release date: 2026-06-17)

• Primary citation: Ren, Y.,Pavlovskyil, A.,Liu, X.,Gerhart-Hines, Z.; Mechanistic basis for activation and selectivity of NK2R by endogenous and synthetic peptide agonists; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.4 Å)