9W0M

Cryo-EM structure of S1P2 in complex with heterotrimeric G protein

Summary for 9W0M

• Entry DOI: 10.2210/pdb9w0m/pdb
• EMDB information: 65508
• Descriptor: Sphingosine 1-phosphate receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (4 entities in total)
• Functional Keywords: g protein-coupled receptor, bitter taste receptor 14, bitter taste receptor 46, ligand binding, signal transduction, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 129784.63

Authors

Wu, B.,Zhao, Q.,Tan, Q. (deposition date: 2025-07-24, release date: 2026-06-03)

• Primary citation: Wu, Y.,Chen, Q.,Wang, H.,Liu, K.,Wei, J.,Wang, M.,Chen, K.,Zhu, Y.,Han, S.,Yi, C.,Ma, L.,Schnapp, G.,Pautsch, A.,Gnamm, C.,Grauert, M.,Schmidt, E.,Tan, Q.,Wu, B.,Zhao, Q.; Structural basis of allosteric and bitopic ligands binding in sphingosine-1-phosphate receptors 2 and 3.; Protein Cell, 2025; PubMed: 40851516; DOI: 10.1093/procel/pwaf068

Experimental method

ELECTRON MICROSCOPY (3.8 Å)