9VVO

cryo-EM structure of gastric proton pump bound to YK01

This is a non-PDB format compatible entry.

Summary for 9VVO

• Entry DOI: 10.2210/pdb9vvo/pdb
• EMDB information: 65385
• Descriptor: Sodium/potassium-transporting ATPase subunit alpha, Potassium-transporting ATPase subunit beta, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (8 entities in total)
• Functional Keywords: p-type atpase, transporters, gastric, p-cabs, proton pump, membrane protein
• Biological source: Sus scrofa (pig); More
• Total number of polymer chains: 2
• Total formula weight: 144564.52

Authors

Saito, H.,Abe, K. (deposition date: 2025-07-16, release date: 2026-01-14)

• Primary citation: Umekubo, N.,Hashizume, A.,Saito, H.,Kato, S.,Kanai, C.,Gopalasingam, C.C.,Gerle, C.,Shigematsu, H.,Yoshimori, A.,Abe, K.,Yokoshima, S.; Design, Synthesis, and Structural Analysis of an Inhibitor of the Gastric Proton Pump with a Diaza-tricyclic Skeleton; Org.Biomol.Chem., 2025; DOI: 10.1039/D5OB01828E

Experimental method

ELECTRON MICROSCOPY (2.66 Å)