9VUR

Crystal Structure of TEAD2 in a covalent complex with LC-TEAD01

This is a non-PDB format compatible entry.

Summary for 9VUR

• Entry DOI: 10.2210/pdb9vur/pdb
• Descriptor: Transcriptional enhancer factor TEF-4, ~{N}-[[1-(4-propoxyphenyl)-1,2,3-triazol-4-yl]methyl]ethanesulfonamide (3 entities in total)
• Functional Keywords: transcription factor, covalent ligand binding, protein-ligand complex, tea domain, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 53250.34

Authors

Miao, Y.H.,Chen, S.J.,Yang, X. (deposition date: 2025-07-13, release date: 2026-07-22)

• Primary citation: Miao, Y.H.,Chen, S.J.; In situ double-click chemistry rapid generation of novel and potent covalent TEAD inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.66 Å)