9VPG

Cryo-EM structure of human urate transporter GLUT9 bound to a selective inhibitor SG4

This is a non-PDB format compatible entry.

Summary for 9VPG

• Entry DOI: 10.2210/pdb9vpg/pdb
• EMDB information: 65253
• Descriptor: Solute carrier family 2, facilitated glucose transporter member 9, (~{E})-3-[2-(4-hydroxyphenyl)-4-oxidanylidene-3~{H}-quinazolin-8-yl]-~{N}-propan-2-yl-prop-2-enamide (2 entities in total)
• Functional Keywords: complex, selective inhibitor, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 63564.47

Authors

Pan, X.,Shen, Z.,Luo, Z. (deposition date: 2025-07-03, release date: 2026-05-13)

• Primary citation: Zhao, Z.,Sun, Z.,Shen, Z.,Zheng, F.,Zhang, X.,Luo, Z.,He, Y.,Xu, Y.,Wu, Z.,Ke, J.,Li, J.,Wu, T.,Zhang, Q.,Tian, Y.,Pan, X.,Pang, J.,Chen, J.; Selective GLUT9 inhibitors for hyperuricemia via intestinal mechanism; Acta Pharm Sin B, 2026; DOI: 10.1016/j.apsb.2026.03.011

Experimental method

ELECTRON MICROSCOPY (3.14 Å)