9VOY

EGFR T790M/L858R mutant in complex with covalent inhibitor TAS6417

Summary for 9VOY

• Entry DOI: 10.2210/pdb9voy/pdb
• Descriptor: Epidermal growth factor receptor, N-[(5P,8S,10R)-4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: egf receptor kinase mutant t790m, l858r, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38088.58

Authors

Suzuki, T.,Uno, T. (deposition date: 2025-07-02, release date: 2026-07-15)

• Primary citation: Uno, T.,Suzuki, T.; Discovery of Zipalertinib (TAS6417) as a Novel, Potent, Mutant Selective, and Orally Available Covalent EGFR Inhibitor Targeting EGFR Exon 20 Insertion Mutations in Non-Small Cell Lung Cancer; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.67 Å)