9VOY
EGFR T790M/L858R mutant in complex with covalent inhibitor TAS6417
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 330 | 37479.4 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | N-[(5P,8S,10R)-4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide | non-polymer | 396.4 | 1 | Chemie (X9H) PubChem (117918742) | |||
| 3 | C, D, E, F, G... (A) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) PubChem (312) | |||
| 4 | I (A) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 693 | - | expression tag |
| Ser 694 | - | expression tag |
| Met 695 | - | expression tag |
| Met 790 | Thr 790 | variant |
| Arg 858 | Leu 858 | variant |
| Ala 865 | Glu 865 | conflict |
| Ala 866 | Glu 866 | conflict |
| Ala 867 | Lys 867 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37479.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 609.2 | |
| All* | Total formula weight | 38088.6 |
