9VEE

The cryo-EM structure of human Piezo2-MDFIC2 complex (composite map)

Summary for 9VEE

• Entry DOI: 10.2210/pdb9vee/pdb
• EMDB information: 65005
• Descriptor: Piezo-type mechanosensitive ion channel component 2,Green fluorescent protein, MyoD family inhibitor domain-containing protein 2 (2 entities in total)
• Functional Keywords: piezo2, mechanosensitive channel, mdfic2, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 1117308.63

Authors

Zhang, Y.,Dai, F.,Zhou, Z.,Dai, F.,Cheng, D.,Ma, X.,Omidkhoda, S.F.,Clarke, J.,Zhang, H.,Laden, M.,Guo, Y.,Li, J.V.,Liu, R.,Wong, E.S.,Zhang, Y.,Cox, C.D. (deposition date: 2025-06-09, release date: 2026-04-08, Last modification date: 2026-05-06)

• Primary citation: Zhang, Y.,Dai, F.; MDFIC2 is a sensory neuron-specific PIEZO channel auxiliary subunit; Proc.Natl.Acad.Sci.USA, 2026

Experimental method

ELECTRON MICROSCOPY (3.36 Å)