9V1H

Cryo-EM structure of Gi-coupled NPFF2R in complex with GUB08248

Summary for 9V1H

• Entry DOI: 10.2210/pdb9v1h/pdb
• EMDB information: 64693
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, scFv16, ... (6 entities in total)
• Functional Keywords: npff2r, prolactin-releasing peptide, membrane protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 165843.95

Authors

Zhao, L.,Li, X.,Li, S.,Yuan, Q. (deposition date: 2025-05-19, release date: 2026-02-04)

• Primary citation: Li, X.,Li, S.,Yuan, Q.; Molecular basis for cross-activation of NPFF2R by a short PrRP-related peptide; Acta Pharmacol.Sin., 2026; DOI: 10.1038/s41401-025-01741-1

Experimental method

ELECTRON MICROSCOPY (2.85 Å)