9UVX

Cryo-EM structure of Vasopressin receptor 2 (V2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with OPC51803, focused on receptor

This is a non-PDB format compatible entry.

Summary for 9UVX

• Entry DOI: 10.2210/pdb9uvx/pdb
• EMDB information: 64540
• Descriptor: Vasopressin V2 receptor,Soluble cytochrome b562, 2-[(5~{R})-1-(2-chloranyl-4-pyrrolidin-1-yl-phenyl)carbonyl-2,3,4,5-tetrahydro-1-benzazepin-5-yl]-~{N}-propan-2-yl-ethanamide (2 entities in total)
• Functional Keywords: gpcr, v2r, vasopressin, opc51803, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 54048.98

Authors

Kojima, A.,Kawakami, K.,Kobayashi, K.,Matsui, T.E.,Fukuda, M.,Kato, H.E. (deposition date: 2025-05-11, release date: 2026-05-06)

• Primary citation: Kojima, A.,Kawakami, K.,Kobayashi, N.,Kobayashi, K.,Matsui, T.E.,Uemoto, K.,Gu, Y.,Fukuda, M.,Kato, H.E.; A Rapid and Universal Pipeline for High-Resolution GPCR Structure Determination through In Silico Construct Optimization and de novo Protein Design; Biorxiv, 2026; DOI: 10.64898/2026.04.02.716066

Experimental method

ELECTRON MICROSCOPY (3.31 Å)