9UVX
Cryo-EM structure of Vasopressin receptor 2 (V2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with OPC51803, focused on receptor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vasopressin V2 receptor,Soluble cytochrome b562 | polymer | 486 | 53595.0 | 1 | UniProt (P30518) UniProt (P0ABE7) Pfam (PF00001) | Homo sapiens (human) | V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor,Cytochrome b-562 |
| 2 | B (A) | 2-[(5~{R})-1-(2-chloranyl-4-pyrrolidin-1-yl-phenyl)carbonyl-2,3,4,5-tetrahydro-1-benzazepin-5-yl]-~{N}-propan-2-yl-ethanamide | non-polymer | 454.0 | 1 | Chemie (A1L9O) |
Sequence modifications
A: 1 - 236 (UniProt: P30518)
A: 237 - 342 (UniProt: P0ABE7)
A: 343 - 449 (UniProt: P30518)
| PDB | External Database | Details |
|---|---|---|
| Met -30 | - | initiating methionine |
| Lys -29 | - | expression tag |
| Thr -28 | - | expression tag |
| Ile -27 | - | expression tag |
| Ile -26 | - | expression tag |
| Ala -25 | - | expression tag |
| Leu -24 | - | expression tag |
| Ser -23 | - | expression tag |
| Tyr -22 | - | expression tag |
| Ile -21 | - | expression tag |
| Phe -20 | - | expression tag |
| Cys -19 | - | expression tag |
| Leu -18 | - | expression tag |
| Val -17 | - | expression tag |
| Phe -16 | - | expression tag |
| Ala -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Tyr -13 | - | expression tag |
| Lys -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 243 | Met 29 | engineered mutation |
| Ile 338 | His 124 | engineered mutation |
| Leu 342 | Arg 128 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Leu 450 | - | expression tag |
| Glu 451 | - | expression tag |
| Val 452 | - | expression tag |
| Leu 453 | - | expression tag |
| Phe 454 | - | expression tag |
| Gln 455 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 53595.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 454.0 | |
| All* | Total formula weight | 54049.0 |
