9UO1

Cryo-EM structure of human organic solute transporter Ost-alpha/beta bound with DHEAS

Summary for 9UO1

• Entry DOI: 10.2210/pdb9uo1/pdb
• EMDB information: 64369
• Descriptor: Organic solute transporter subunit alpha, Organic solute transporter subunit beta, (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, ... (9 entities in total)
• Functional Keywords: substrate, transport, heterodimer, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 132169.38

Authors

Yang, X.,Xu, E. (deposition date: 2025-04-24, release date: 2025-12-10, Last modification date: 2026-02-04)

• Primary citation: Yang, X.,Cui, N.,Li, T.,He, X.,Zhang, H.,Wu, C.,Li, Y.,Ma, X.,Xu, E.; Structures of Ostalpha/beta reveal a unique fold and bile acid transport mechanism; Nature, 2026; DOI: 10.1038/s41586-025-10029-7

Experimental method

ELECTRON MICROSCOPY (2.9 Å)