9UO1
Cryo-EM structure of human organic solute transporter Ost-alpha/beta bound with DHEAS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Organic solute transporter subunit alpha | polymer | 351 | 38967.1 | 2 | UniProt (Q86UW1) Pfam (PF03619) | Homo sapiens (human) | OST-alpha,Solute carrier family 51 subunit alpha |
| 2 | B, D (B, D) | Organic solute transporter subunit beta | polymer | 141 | 15943.9 | 2 | UniProt (Q86UW2) Pfam (PF15048) | Homo sapiens (human) | OST-beta,Solute carrier family 51 subunit beta |
| 3 | DA, E, F, HA (A, C) | (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate | non-polymer | 742.0 | 4 | Chemie (76F) | |||
| 4 | G, KA (A, C) | PHOSPHATIDYL ETHANOL | non-polymer | 717.0 | 2 | Chemie (P0E) | |||
| 5 | H, LA (A, C) | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 510.7 | 2 | Chemie (LPE) | |||
| 6 | BA, CA, EA, FA, FB... (A, B, D, C) | CHOLESTEROL | non-polymer | 386.7 | 32 | Chemie (CLR) | |||
| 7 | AB, BB, CB, T, U... (C, A) | PALMITIC ACID | non-polymer | 256.4 | 12 | Chemie (PLM) | |||
| 8 | AA, DB, EB, Z (A, C) | 17-oxoandrost-5-en-3beta-yl hydrogen sulfate | non-polymer | 368.5 | 4 | Chemie (ZWY) | |||
| 9 | IB, JB (A, C) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 340 (UniProt: Q86UW1)
B, D: 1 - 128 (UniProt: Q86UW2)
| PDB | External Database | Details |
|---|---|---|
| Gly 341 | - | expression tag |
| Gly 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Asp 344 | - | expression tag |
| Tyr 345 | - | expression tag |
| Lys 346 | - | expression tag |
| Asp 347 | - | expression tag |
| Asp 348 | - | expression tag |
| Asp 349 | - | expression tag |
| Asp 350 | - | expression tag |
| Lys 351 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 129 | - | expression tag |
| Gly 130 | - | expression tag |
| Ser 131 | - | expression tag |
| His 132 | - | expression tag |
| His 133 | - | expression tag |
| His 134 | - | expression tag |
| His 135 | - | expression tag |
| His 136 | - | expression tag |
| His 137 | - | expression tag |
| His 138 | - | expression tag |
| His 139 | - | expression tag |
| His 140 | - | expression tag |
| His 141 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 109822.0 | |
| Non-Polymers* | Number of molecules | 56 |
| Total formula weight | 22347.4 | |
| All* | Total formula weight | 132169.4 |
