9UO1
Cryo-EM structure of human organic solute transporter Ost-alpha/beta bound with DHEAS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Organic solute transporter subunit alpha | polymer | 351 | 38967.1 | 2 | UniProt (Q86UW1) Pfam (PF03619) | Homo sapiens (human) | OST-alpha,Solute carrier family 51 subunit alpha |
| 2 | B, D (B, D) | Organic solute transporter subunit beta | polymer | 141 | 15943.9 | 2 | UniProt (Q86UW2) Pfam (PF15048) | Homo sapiens (human) | OST-beta,Solute carrier family 51 subunit beta |
| 3 | DA, E, F, HA (A, C) | (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate | non-polymer | 742.0 | 4 | Chemie (76F) PubChem (53479626) PubChem (76042081) PubChem (134768091) PubChem (156587308) PubChem (162806467) | |||
| 4 | G, KA (A, C) | PHOSPHATIDYL ETHANOL | non-polymer | 717.0 | 2 | Chemie (P0E) PubChem (21157550) PubChem (73745795) PubChem (52946593) | |||
| 5 | H, LA (A, C) | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 510.7 | 2 | Chemie (LPE) PubChem (3855) PubChem (9546711) PubChem (446876) | |||
| 6 | BA, CA, EA, FA, FB... (A, B, D, C) | CHOLESTEROL | non-polymer | 386.7 | 32 | Chemie (CLR) PubChem (304) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (638019) PubChem (1549081) PubChem (1553803) PubChem (5283629) PubChem (5284644) PubChem (5315842) PubChem (6419195) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (16219173) PubChem (16758052) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (176980071) PubChem (45044259) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (23423981) PubChem (49853509) PubChem (44654663) PubChem (46937002) PubChem (59274407) PubChem (50990013) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (5997) PubChem (1551269) PubChem (90070115) PubChem (52934537) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (56621683) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (57915018) PubChem (57939063) PubChem (138967089) PubChem (58428240) PubChem (58445498) PubChem (139566851) PubChem (58663286) PubChem (15939944) PubChem (59450329) PubChem (59628412) PubChem (171828367) PubChem (173516975) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (101624109) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 7 | AB, BB, CB, T, U... (C, A) | PALMITIC ACID | non-polymer | 256.4 | 12 | Chemie (PLM) | |||
| 8 | AA, DB, EB, Z (A, C) | 17-oxoandrost-5-en-3beta-yl hydrogen sulfate | non-polymer | 368.5 | 4 | Chemie (ZWY) PubChem (12594) PubChem (83891) PubChem (6604099) PubChem (13474726) PubChem (24867494) PubChem (50989979) PubChem (5244) PubChem (135337) PubChem (9799421) PubChem (10317945) PubChem (71752218) PubChem (73759687) PubChem (87399275) PubChem (122130634) PubChem (124318506) PubChem (124784292) PubChem (124784293) PubChem (124910878) PubChem (126969889) PubChem (133126796) PubChem (162910008) PubChem (165431259) | |||
| 9 | IB, JB (A, C) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 340 (UniProt: Q86UW1)
B, D: 1 - 128 (UniProt: Q86UW2)
| PDB | External Database | Details |
|---|---|---|
| Gly 341 | - | expression tag |
| Gly 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Asp 344 | - | expression tag |
| Tyr 345 | - | expression tag |
| Lys 346 | - | expression tag |
| Asp 347 | - | expression tag |
| Asp 348 | - | expression tag |
| Asp 349 | - | expression tag |
| Asp 350 | - | expression tag |
| Lys 351 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 129 | - | expression tag |
| Gly 130 | - | expression tag |
| Ser 131 | - | expression tag |
| His 132 | - | expression tag |
| His 133 | - | expression tag |
| His 134 | - | expression tag |
| His 135 | - | expression tag |
| His 136 | - | expression tag |
| His 137 | - | expression tag |
| His 138 | - | expression tag |
| His 139 | - | expression tag |
| His 140 | - | expression tag |
| His 141 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 109822.0 | |
| Non-Polymers* | Number of molecules | 56 |
| Total formula weight | 22347.4 | |
| All* | Total formula weight | 132169.4 |
