9U5U

The 1:1 cryo-EM structure of BAP1/ASXL1-K351Ub in complex with H2AK119Ub nucleosome

Summary for 9U5U

• Entry DOI: 10.2210/pdb9u5u/pdb
• EMDB information: 63884
• Descriptor: Histone H3.2, Histone H4, Histone H2A type 1-B/E, ... (9 entities in total)
• Functional Keywords: pr-dub, nucleosome, h2ak119ub, bap1, bap1/asxl1, asxl1 k351ub the 2:1 complex of bap1-asxl1-k351ub and h2ak119ub nucleosome, nuclear protein/dna, nuclear protein-dna complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 14
• Total formula weight: 313339.92

Authors

Ai, H.S.,Liu, L. (deposition date: 2025-03-21, release date: 2026-01-14)

• Primary citation: Zhang, T.,Zheng, J.,Tong, Z.,Deng, Z.,He, Z.,Wu, X.,Wang, M.,Du, Y.,Xu, Z.,Tao, S.,Tian, X.,Deng, H.,Pan, M.,Ai, H.,Liu, L.; Unique Gluing Effect of ASXL1 K351 Monoubiquitination Stimulates PR-DUB-Mediated Nucleosomal H2AK119Ub Deubiquitination; Biorxiv, 2025; DOI: 10.1101/2025.04.25.650627

Experimental method

ELECTRON MICROSCOPY (3.12 Å)