9U18

Crystal structure of the NKX2.1 homeodomain in complex with a 12-bp DNA duplex containing a CAAG motif

Summary for 9U18

• Entry DOI: 10.2210/pdb9u18/pdb
• Descriptor: CAAG-containing 12bp forward strand, 12bp reverse complementary, Homeobox protein Nkx-2.1, ... (5 entities in total)
• Functional Keywords: nkx2.1, homeobox, transcription factor, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 29452.12

Authors

Malecka, M.Z.,Bommer, M.,Heinemann, U. (deposition date: 2026-01-29, release date: 2026-05-20)

• Primary citation: Lenihan-Geels, F.,Proft, S.,Bommer, M.,Heinemann, U.,Seelow, D.,Opitz, R.,Krude, H.,Schuelke, M.,Malecka, M.; Quantification of the effects of single nucleotide variants in NKX2.1 transcription factor binding sites; Biorxiv, 2026; DOI: 10.64898/2026.02.27.708450

Experimental method

X-RAY DIFFRACTION (1.5 Å)