9TYG

Structure of the MAP2K MEK1 in an inactive conformation in complex with its substrate MAPK ERK2

Summary for 9TYG

Entry DOI	10.2210/pdb9tyg/pdb
EMDB information	56418 56419 56420
Descriptor	Dual specificity mitogen-activated protein kinase kinase 1,Uncharacterized protein,Dual specificity mitogen-activated protein kinase kinase 1, Mitogen-activated protein kinase 1, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	protein kinases, phosphoryl transfer, mapk, map2k, cancer signaling, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	87585.25
Authors	von Velsen, J.,Juyoux, P.,Bowler, M.W. (deposition date: 2026-01-19, release date: 2026-02-11)
Primary citation	von Velsen, J.,Juyoux, P.,Piasentin, N.,Fisher, H.,Lapouge, K.,Vadas, O.,Gervasio, F.L.,Bowler, M.W. Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1 Biorxiv, 2026 Cited by DOI: 10.64898/2026.01.19.700303 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation