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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9TYG

Structure of the MAP2K MEK1 in an inactive conformation in complex with its substrate MAPK ERK2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0000187biological_processobsolete activation of MAPK activity
A0003056biological_processregulation of vascular associated smooth muscle contraction
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004708molecular_functionMAP kinase kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005078molecular_functionMAP-kinase scaffold activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006935biological_processchemotaxis
A0006979biological_processresponse to oxidative stress
A0007165biological_processsignal transduction
A0007528biological_processneuromuscular junction development
A0008285biological_processnegative regulation of cell population proliferation
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0014044biological_processSchwann cell development
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0019901molecular_functionprotein kinase binding
A0030182biological_processneuron differentiation
A0030295molecular_functionprotein kinase activator activity
A0030335biological_processpositive regulation of cell migration
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031267molecular_functionsmall GTPase binding
A0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
A0032402biological_processmelanosome transport
A0032839cellular_componentdendrite cytoplasm
A0032872biological_processregulation of stress-activated MAPK cascade
A0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
A0034111biological_processnegative regulation of homotypic cell-cell adhesion
A0036064cellular_componentciliary basal body
A0038127biological_processERBB signaling pathway
A0038133biological_processERBB2-ERBB3 signaling pathway
A0042552biological_processmyelination
A0043204cellular_componentperikaryon
A0043410biological_processpositive regulation of MAPK cascade
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0044877molecular_functionprotein-containing complex binding
A0045893biological_processpositive regulation of DNA-templated transcription
A0045933biological_processpositive regulation of muscle contraction
A0047496biological_processvesicle transport along microtubule
A0048009biological_processinsulin-like growth factor receptor signaling pathway
A0048313biological_processGolgi inheritance
A0048471cellular_componentperinuclear region of cytoplasm
A0048678biological_processresponse to axon injury
A0048812biological_processneuron projection morphogenesis
A0051384biological_processresponse to glucocorticoid
A0070328biological_processtriglyceride homeostasis
A0070371biological_processERK1 and ERK2 cascade
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0090170biological_processregulation of Golgi inheritance
A0090398biological_processcellular senescence
A0097110molecular_functionscaffold protein binding
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098978cellular_componentglutamatergic synapse
A0106310molecular_functionprotein serine kinase activity
A1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
A2000641biological_processregulation of early endosome to late endosome transport
A2001171biological_processpositive regulation of ATP biosynthetic process
B0000165biological_processMAPK cascade
B0001784molecular_functionphosphotyrosine residue binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004707molecular_functionMAP kinase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005769cellular_componentearly endosome
B0005770cellular_componentlate endosome
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005901cellular_componentcaveola
B0005925cellular_componentfocal adhesion
B0006357biological_processregulation of transcription by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0006935biological_processchemotaxis
B0007165biological_processsignal transduction
B0007166biological_processcell surface receptor signaling pathway
B0007173biological_processepidermal growth factor receptor signaling pathway
B0007268biological_processchemical synaptic transmission
B0007611biological_processlearning or memory
B0008286biological_processinsulin receptor signaling pathway
B0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
B0010759biological_processpositive regulation of macrophage chemotaxis
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0014044biological_processSchwann cell development
B0016301molecular_functionkinase activity
B0019902molecular_functionphosphatase binding
B0031143cellular_componentpseudopodium
B0032206biological_processpositive regulation of telomere maintenance
B0032872biological_processregulation of stress-activated MAPK cascade
B0034198biological_processcellular response to amino acid starvation
B0035094biological_processresponse to nicotine
B0035556biological_processintracellular signal transduction
B0035578cellular_componentazurophil granule lumen
B0038127biological_processERBB signaling pathway
B0038133biological_processERBB2-ERBB3 signaling pathway
B0042552biological_processmyelination
B0042802molecular_functionidentical protein binding
B0043415biological_processpositive regulation of skeletal muscle tissue regeneration
B0045202cellular_componentsynapse
B0045542biological_processpositive regulation of cholesterol biosynthetic process
B0045880biological_processpositive regulation of smoothened signaling pathway
B0048009biological_processinsulin-like growth factor receptor signaling pathway
B0051403biological_processstress-activated MAPK cascade
B0051493biological_processregulation of cytoskeleton organization
B0061514biological_processinterleukin-34-mediated signaling pathway
B0070098biological_processchemokine-mediated signaling pathway
B0070371biological_processERK1 and ERK2 cascade
B0070849biological_processresponse to epidermal growth factor
B0072584biological_processcaveolin-mediated endocytosis
B0072686cellular_componentmitotic spindle
B0090170biological_processregulation of Golgi inheritance
B0097542cellular_componentciliary tip
B0106310molecular_functionprotein serine kinase activity
B0120041biological_processpositive regulation of macrophage proliferation
B0150078biological_processpositive regulation of neuroinflammatory response
B1904813cellular_componentficolin-1-rich granule lumen
B2000641biological_processregulation of early endosome to late endosome transport
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGAYGMVCsAydnvnkvrv.........AIKK
ChainResidueDetails
BILE31-LYS55
ALEU80-LYS103
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpsNLLL
ChainResidueDetails
BVAL145-LEU157
AILE192-VAL204
site_idPS01351
Number of Residues103
DetailsMAPK MAP kinase signature. FehqtycqrtlREikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqilrglkyihsanvlh..........RDlKpsnlllnttC
ChainResidueDetails
BPHE59-CYS161
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15543157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17880056","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18951019","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19019675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19706763","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21310613","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19161339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EQH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19161339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EQF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsSite: {"description":"Cleavage; by anthrax lethal factor"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by BRAF and RAF1","evidences":[{"source":"PubMed","id":"10409742","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20956560","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29433126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8131746","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by BRAF and RAF1","evidences":[{"source":"PubMed","id":"20956560","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29433126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8131746","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues288
DetailsDomain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues18
DetailsDNA binding: {}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsMotif: {"description":"TXY","evidences":[{"source":"PubMed","id":"18760948","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsMotif: {"description":"Cytoplasmic retention motif","evidences":[{"source":"PubMed","id":"18760948","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues6
DetailsMotif: {"description":"Nuclear translocation motif","evidences":[{"source":"PubMed","id":"18760948","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by SGK1","evidences":[{"source":"PubMed","id":"19447520","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by MAP2K1 and MAP2K2","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by MAP2K1 and MAP2K2","evidences":[{"source":"PubMed","id":"19053285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19494114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"19060905","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18760948","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2026-04-01

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